Optimizing Dvl PDZ domain inhibitor by exploring chemical space
نویسندگان
چکیده
منابع مشابه
Optimizing Dvl PDZ domain inhibitor by exploring chemical space
Because of advances in the high-throughput screening technology, identification of a hit that can bind to a target protein has become a relatively easy task; however, in the process of drug discovery, the following hit-to-lead and lead optimization still remain challenging. In a typical hit-to-lead and lead optimization process, the analogues of the most promising hits are synthesized for the d...
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ژورنال
عنوان ژورنال: Journal of Computer-Aided Molecular Design
سال: 2008
ISSN: 0920-654X,1573-4951
DOI: 10.1007/s10822-008-9236-1